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What is Kliofem?

Kliofem is a continuous, combined hormone replacement therapy treatment (HRT) for postmenopausal women. It contains two synthetic hormones called estradiol and norethisterone, which are similar to the natural sex hormone oestrogen and progesterone, respectively.

Together, the synthetic hormones counteract the symptoms of the menopause.

The estradiol supplements the falling levels of the hormone oestrogen, while the norethisterone counteracts the effect of the estradiol, preventing the endometrium from growing excessively.

What is the menopause?

The menopause is the time in a woman’s life when her body stops preparing itself for pregnancy. Menstruation cycles and ovulation, which both slow down before stopping completely.

During the menopause, oestrogen levels in the body fall, which cause a number of symptoms such as:

• Difficulty sleeping
• Hot flushes
• Lower sex drive (libido)
• Mood swings
• Night Sweats
• Vaginal dryness

Typically, these symptoms begin between the ages of 45 and 55, with many women experiencing symptoms around the age of 51, according to the NHS.

If a woman particularly suffers from these symptoms, HRT can be prescribed to balance the hormones in the body.

How to take Kliofem?

Always follow the dosage prescribed by a healthcare professional.

Kliofem should be taken once daily at the same time each day.

Kliofem can be taken with or without food.

Swallow the tablets whole with a glass of water.

Do not crush or chew Kliofem tablets.

What should I do if I forget to take Kliofem when I should?

If you miss a dose, take it as soon as you remember.

If you miss a dose, and it has been 12 hours since your last dose, or if it is nearly time for your next dose, skip the missed tablet and take the next tablet as normal.

Do not take more than the prescribed dose of Kliofem. If you accidentally take more Kliofem than prescribed, seek immediate medical attention.

Side effects and cautions of Kliofem

Before you take Kliofem, you must read the enclosed patient information leaflet.

You can view the patient information leaflet for Kliofem online.

If you have any concerns or questions regarding any of the information detailed within the patient information leaflet, speak to your doctor or ask a pharmacist.

Who should not use Kliofem?

Kliofem should not be used by women who:

• Had a disease caused by a blood clot in the past such as a heart attack, stroke or angina
• Have a blood clotting disorder
• Have a rare blood condition called porphyria (inherited)
• Have any unexplained vaginal bleeding
• Have excessive thickness of the endometrium (endometrial hyperplasia)
• Have or had any blood clots in the veins (deep vein thrombosis or pulmonary embolism)
• Have or had liver disease
• Have, had or suspect they have breast cancer
• Have, had, or suspected cancer of the womb lining (endometrial cancer)

Side effects

All medications carry the risk of side effects, though not everyone experiences them. Before taking your medication, it is important to familiarise yourself with the possible risks associated with your treatment by reading the patient information leaflet. This document can be found enclosed in your treatment.

Possible side effects of Kliofem may include:

• Breast pain or tenderness
• Changes in sex drive (libido)
• Dizziness
• Fluid retention
• Gallbladder disease
• Headaches or migraine
• Increased risk of blood clots
• Indigestion
• Inflammation of the pancreas (pancreatitis)
• Menstrual bleeding or spotting
• Mood swings
• Nausea
• Tiredness
• Vaginal thrush
• Weight changes

This is not a complete list of side effects associated with Kliofem. Further information regarding the safety of Kliofem can be found in the patient information leaflet.

Allergies

Do not take Kliofem if you are allergic to any of the ingredients.

If you experience an allergic reaction to Kliofem, stop taking it and seek medical attention immediately. Go straight to your nearest A&E department. Remember to take the packaging and any remaining tablets with you, so that doctors treating you know exactly what you have taken.

Pregnancy and breastfeeding

Kliofem should not be used by women who are pregnant or breastfeeding. If you discover you are pregnant while taking Kliofem, stop treatment immediately and consult a doctor.

Kliofem is not a form of contraception. If it has been less than 12 months since your last period, or you are under the age of 50, you may need to use additional contraception – such as condoms – to prevent pregnancy.

Other safety information

Always read the patient information leaflet before you start taking Kliofem.

Use our online medical form to list all the medication you are taking, including those prescribed by your doctor, or bought over the counter. This is important information for our online prescribers.

Do not take Kliofem past the expiry date printed on the packaging.

Never dispose of medicines via household or water waste, as this can damage the environment. Instead, take any unwanted or expired medication to your local pharmacy and ask them to dispose them safely for you.

Always store Kliofem out of sight and reach from children and pets.

Never share your tablets with anybody else – even if they are experiencing the same symptoms or have been diagnosed with the same condition as you.